1Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
In the religion of Islam, fasting is obligatory for healthy adults during Ramadan. Millions of Muslims around the world practice fasting in this holy month which may cause different metabolic and hormonal changes due to the restrictions in regular caloric intake. This article was aimed to review some possible effects of Ramadan fasting on the endocrine system which has a great impact on physiological and cellular processes through a wide variety of hormones. Despite various studies regarding the impact of Islamic fasting on a number of hormonal values, yet there is not any obvious consensus on its impact on human health. In conclusion, this article recommended normal people to continue fasting during this holy month because despite the modifications that occur in the secretion pattern of some hormones, it causes no major alteration in the health of normal subjects; it is also effective for maintenance of remission in some diseases.
Mesbahzadeh B, Ghiravani Z, Mehrjoofard H. Effect of Ramadan fasting on secretion of sex hormones in healthy single males. East Mediterr Health J. 2005; 11(5-6):1120-3.
Bogdan A, Bouchareb B, Touitou Y. Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans? Life Sci. 2001; 68(14):1607-15.
Azizi F. Islamic fasting and health. Ann NutrMetab. 2010; 56(4):273-82.
Mauzzam MM. Ramadan fasting and medical science. Bangladesh J Med Sci. 1996; 3(1):8-15.
Bener A, Galadari S, Gillett M, Osman N, Al-Taneiji H, Al-Kuwaiti MH, et al. Fasting during the holy month of Ramadan does not change the composition of breast milk. Nutr Res. 2001; 21(6):859-64.
Einollahi B, Lessan-Pezeshki M, Simforoosh N, Nafar M, Pour-Reza-Gholi F, Firouzan A, et al. Impact of Ramadan fasting on renal allograft function. Transplant Proc. 2005; 37(7):3004-5.
Ahmadinejad Z, Ziaee V, Rezaee M, Yarmohammadi L, Shaikh H, Bozorgi F, et al. The Effect of Ramadan fasting on thyroid hormone profile: a cohort study. Pak J Biol Sci. 2006; 9(10):1999-2002.
Feizollahzadeh S, Rasuli J, Kheirouri S, Alizadeh M. Augmented plasma adiponectin after prolonged fasting during ramadan in men. Health PromotPerspect. 2014; 4(1):77-81.
Bahreyni S, Mazidi M, Rezaie P, Vakili R, Norouzy A, Hashemy SI, et al. The effects of Ramadan fasting on the level of sex hormones in premenarche girls in Mashhad, Iran. J Fast Health. 2015; 3(1):43-9.
Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol. 2004; 25(3-4):177-95.
Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Rev. 2005; 9(1):25-39.
Bogdana A, Boucharebb B, Touitoua Y. Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal–time as a synchronizer in humans? Life Sci. 2000; 68(14):1607-15.
Jiang X, Liu H, Chen X, Chen PH, Fischer D, Sriraman V, et al. Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor. ProcNatlAcadSci U S A. 2012; 109(31):12491-6.
Pierce JG, Parsons TF. Glycoprotein hormones: structure and function. Annu Rev Biochem. 1981; 50:465-95.
Spicer LJ, Alpizar E. Effects of cytokines on FSHinduced estradiol production by bovine granulosa cells in vitro: dependence on size of follicle. DomestAnimEndocrinol. 1994; 11(1):25-34.
Zangeneh F, Salman Yazdi R, Naghizadeh MM, Abedinia N. Effect of Ramadan fasting on stress neurohormones in women with polycystic ovary syndrome. J Family Reprod Health. 2015; 9(2):51-7.
Shahabi S, Esmaeilzadeh S, Amiri MG, Faramarzi M, Firouzjahee AR, Esmaeili T. Does Islamic fasting affect gonadotropin around female ovulation? Int J FertilSteril. 2010; 4(3):94-7.
El-Migdadi F, El-Akawi Z, Abudheese R, Bashir N. Plasma levels of adrenocorticotropic hormone and cortisol in people living in an environment below sea level (Jordan Valley) during fasting in the month of Ramadan. Horm Res. 2002; 58(6):279-82.
Bouhlel E, Zaouali M, Miled A, Tabka Z, Bigard X, Shephard R. Ramadan fasting and the GH/IGF-1 axis of trained men during submaximal exercise. Ann NutrMetab. 2008; 52(4):261-6.
Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, et al. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J ClinEndocrinolMetab. 1992; 74(4):757-65.
Azizi F. Serum levels of prolactin, thyrotropin, thyroid hormones, TRH responsiveness, and male reproductive function in intermittnt Islamic fasting. Med J Islamic Rep Iran. 1991; 5(3):145-8.
Caglayan EK, Gocmen AY, Delibas N. Effects of long-term fasting on female hormone levels: Ramadan model. ClinExpObstet Gynecol. 2014; 41(1):17-9.
Harber VJ, Sutton JR. Endorphins and exercise. Sports Med. 1984; 1(2):154-71.
Gilman SC, Schwartz JM, Milner RJ, Bloom FE, Feldman JD. Beta-endorphin enhances lymphocyte proliferative responses. ProcNatlAcadSci U S A. 1982; 79(13):4226-30.
Seifer DB, Collins RL. Current concepts of betaendorphin physiology in female reproductive dysfunction. FertilSteril. 1990; 54(5):757-71.
Shu-Dong T, Phillips DM, Halmi N, Krieger D, Bardin CW. Beta-endorphin is present in the male reproductive tract of five species. BiolReprod. 1982; 27(3):755-64.
Lahdimawan A, Handono K, Indra MR, Prawiro SR. Effect of Ramadan fasting on the ability of serum, PBMC and macrophages from healthy subjects to kill M. Tuberculosis. J Pharm Biol Sci. 2014; 9:24-9.
Mansi K, Amneh M. Impact of Ramadan fasting on metabolism and on serum levels of some hormones among healthy Jordanian students. J Med Sci. 2007; 7(5):755-61.
Bahrayni S, Vakili R, Nematy M, Norouzy A, Hashemy SI, Ebrahimi M, et al. The effect of Ramadan fasting on thyroid hormones in 9-13 years old pre-menarche girls. J Fast Health. 2013; 1(2):46-52.
Sajid KM, Akhtar M, Malik GQ. Ramadan fasting and thyroid hormone profile. J Pak Med Assoc. 1991; 41(9):213-6.
Dikensoy E, Balat O, Cebesoy B, Ozkur A, Cicek H, Can G. The effect of Ramadan fasting on maternal serum lipids, cortisol levels and fetal development. Arch Gynecol Obstet. 2009; 279(2):119-23.
al-Hadramy MS, Zawawi TH, Abdelwahab SM. Altered cortisol levels in relation to Ramadan. Eur J ClinNutr. 1988; 42(4):359-62.
Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. DevDyn. 2011; 240(3):530-65.
Gnanou JV, Caszo BA, Khalil KM, Abdullah SL, Knight VF, Bidin MZ. Effects of Ramadan fasting on glucose homeostasis and adiponectin levels in healthy adult males. J Diabetes MetabDisord. 2015; 14:55.
M'Guil M, Ragala MA, El Guessabi L, Fellat S, Chraibi A, Chabraoui L, et al. Is Ramadan fasting safe in type 2 diabetic patients in view of the lack of significant effect of fasting on clinical and biochemical parameters, blood pressure, and glycemic control? ClinExpHypertens. 2008; 30(5):339-57.
Khoshdel A, Kheiri S, Hashemi-Dehkordi E, Nasiri J, Shabanian-Borujeni S, Saedi E. The effect of Ramadan fasting on LH, FSH, oestrogen, progesterone and leptin in pregnant women. J ObstetGynaecol. 2014; 34(7):634-8.
Forbes GB, Brown MR, Welle SL, Underwood LE. Hormonal response to overfeeding. Am J ClinNutr. 1989; 49(4):608-11.
Chen J, Tan B, Karteris E, Zervou S, Digby J, Hillhouse EW, et al. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia. 2006; 49(6):1292-302.
Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. ProcNutr Soc. 2001; 60(3):329-39.
Karbowska J, Kochan Z. Role of adiponectin in the regulation of carbohydrate and lipid metabolism. J PhysiolPharmacol. 2006; 57(Suppl 6):103-13.
Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004; 50(9):1511-25.
Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. CurrOpinLipidol. 2002; 13(1):51-9.
Radic R, Nikolic V, Karner I, Kosovic P, Kurbel S, Selthofer R, et al. Circadian rhythm of blood leptin level in obese and non-obese people. CollAntropol. 2003; 27(2):555-61.
Saad MF, Riad-Gabriel MG, Khan A, Sharma A, Michael R, Jinagouda SD, et al. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J ClinEndocrinolMetab. 1998; 83(2):453-9.
Cummings DE, Shannon MH. Roles for ghrelin in the regulation of appetite and body weight. Arch Surg. 2003; 138(4):389-96.
Alzoghaibi MA, Pandi-Perumal SR, Sharif MM, BaHammam AS. Diurnal intermittent fasting during Ramadan: the effects on leptin and ghrelin levels. PloS One. 2014; 9(3):e92214.
Kassab SE, Abdul-Ghaffar T, Nagalla DS, Sachdeva U, Nayar U. Serum leptin and insulin levels during chronic diurnal fasting. Asia Pac J ClinNutr. 2003; 12(4):483-7.
Khafaji HA, Bener A, Osman M, Al Merri A, Al Suwaidi J. The impact of diurnal fasting during Ramadan on the lipid profile, hs-CRP, and serum leptin in stable cardiac patients. Vasc Health Risk Manag. 2012; 8:7-14.