Effect of Resistance Training on Heart Damage Risk Factors in Adult Male Rats Exposed to Nandrolone

Document Type : Research Paper


1 Department of Exercise Physiology, Shooshtar Branch, Islamic Azad University, Shooshtar, Iran.

2 Department of Exercise Physiology, Marvasht Branch, Islamic Azad University, Marvdasht, Iran.

3 Department of Exercise Physiology, Tehran Markaz Branch, Islamic Azad University, Tehran, Iran.



Introduction: Nandrolone (Na) as a derivative of testosterone is used by athletes and non-athletes for different purposes and various results have been reported regarding its use. The aim of this study was to investigate the effect of a period of resistance training (RT) on  SOD, MDA, CRP, cTn-C in the cardiac tissue of Na- exposed rats. Methods: In the present experimental research, 20 male Wistar rats aged 8 to 10 weeks were randomly divided into 4 groups of 5 animals: (1) control, (2) sham, (3) Na (10 mg/kg), (4) Na+RT. The RT group carried out 1-meter ladder climbing 3 sessions weekly for 8 weeks. One-way ANOVA and Tukey's post hoc tests were implemented for analyzing the data (P≤0.05). Results: Levels of SOD were significantly lower in the Na+RT group compared to the control group (P=0.006). However, no significant difference was observed in levels of SOD in the Na group compared to the Na+RT group (P=0.99). Also, the levels of MDA and CRP in the Na+RT group were significantly lower than the Na group (P≤0.05). Histological studies showed that Na intoxication, RT, and RT with Na use had no effect on tissue changes in the study groups. Conclusion: It seems that taking nanderlone with and without resistance training leads to an increase in heart disease risk indicators; However, the risk of heart disease in the conditions of training and abuse of nandrolone is less than the normal condition of this steroid without training.


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  • Receive Date: 15 January 2023
  • Revise Date: 07 May 2023
  • Accept Date: 15 May 2023
  • First Publish Date: 15 May 2023