The Comparison of Serum Levels of IGF1 before and after Fasting in Healthy Adults

Document Type : Research Paper


1 Department of Anatomical Sciences, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.

2 Department of Medical Sciences, Faculty Of Medicine , Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.

3 Department of Community Medicine, Faculty Of Medicine , Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.

4 Student Research Committee, Paramedical Department, Islamic Azad University, Mashhad Branch, Mashhad, Iran.



Introduction: Ramadan is the ninth month of the lunar year in which Muslims avoid eating and drinking from sunrise to sunset. Insulin-like growth factor 1 (IGF1) is a small peptide that circulates in the blood. IGF1 plays an important role in regulating proliferation, differentiation, apoptosis, and transformation. Studies have shown that a small increase in IGF1 levels is associated with an increased risk of prostate, breast, colon, and lung cancer. In this study, the effects of fasting with regular consumption pattern and food avoidance on serum IGF1 concentration in healthy subjects before and after fasting was investigated. Methods: 40 healthy adults in the age group of 18-55 years who were going to fast for about 16 hours a day for at least 20-25 days in Ramadan were included. The first sample was taken one week before Ramadan, and the second one was obtained at the end of Ramadan. After taking 2cc of whole venous blood, sera were isolated, and IGF1 concentration was calculated by quantitative ELISA method using DiaMetra kit. Results: Of the 40 participants in the study, 31 were female, and 9 were male. It was observed that the mean IGF1 before and after fasting was 198.6 ± 77.9 and 146.3 ± 44.5 ng/ml, respectively, with a 52 ng/ml difference. Conclusion: The present study has shown that fasting reduces the level of IGF1, which could be indicative of the benefits of fasting since it could limit the harmful effects of a risk factor of some diseases.


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  • Receive Date: 07 February 2023
  • Revise Date: 20 May 2023
  • Accept Date: 21 May 2023
  • First Publish Date: 21 May 2023