The Simultaneous Effect of Curcumin Extract Supplementation and Aerobic Exercise on Leptin and Adiponectin Gene Expression in Visceral Adipose Tissue of Rats Receiving A High-Fat Diet

Document Type : Research Paper


1 PhD Student, Department of Sports Physiology, Islamic Azad University, Damghan Branch, Damghan, Iran.

2 Assistance Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Damghan Branch, Damghan, Iran.

3 Associate Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Damghan Branch, Damghan, Iran.



Introduction: The use of herbal remedies can be helpful in the prevention and treatment of obesity, overweight, and disorders related to these conditions. However, it is still unclear how aerobic exercise and curcumin supplementation interact with adipose tissue. This study sought to determine how leptin and adiponectin gene expression in visceral adipose tissue of rats fed a high-fat diet would be affected by aerobic exercise and supplementation with curcumin extract. Methods: For this study, 50 male rats were divided into five groups of equal size: control, high-fat diet, curcumin and high-fat diet, aerobic exercise and high-fat diet, and aerobic exercise and curcumin and high-fat diet. Five sessions per week of aerobic exercise were performed for six weeks at a speed of 25 to 29 meters per minute for 20 to 45 minutes. Rats were given high-fat food emulsion in the amount of 0.5 mg/kg of body weight per day for six weeks in order to simulate high-fat food groups. One-way analysis of variance and Tukey's post hoc test were employed in SPSS22 to analyze the results. Results: There is no difference between the short-term effects of aerobic exercise, a high-fat diet, and curcumin extract on adiponectin gene expression in male rats (P=0.05). The short-term effects of aerobic exercise, a high-fat diet, and curcumin extract on the expression of the leptin gene in adipose tissue in male rats are comparable and not significantly different. The findings of this study demonstrated that consumption of curcumin, an antioxidant, and brief exercise have an impact on how the fat gene expresses itself. Conclusions: As a result, when either agent is consumed alone, the expression of the adiponectin and leptin genes in fat decreases or increases, and when both agents are consumed at the same time, the expression of the adiponectin and leptin genes in these cells' fat tissue increases.


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Volume 11, Issue 3
September 2023
  • Receive Date: 05 April 2023
  • Revise Date: 11 June 2023
  • Accept Date: 22 July 2023
  • First Publish Date: 22 July 2023