The Effect of 8 TRX on Myeloperoxidase and Total Antioxidant Capacity as Indicators of Vascular Endothelial Function in Obese Women

Document Type : Research Paper

Authors

1 PhD Candidate, Department of Exercise physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran.

2 Associated Professor, Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran

3 Assistant Professor, Department of Sport Physiology, Faculty of Physical Education, Islamic Azad University, Eslamshahr Branch, Eslamshahr, Iran.

4 Department of Physical Education and Sport Science, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran.

5 Assistant Professor of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

10.22038/jnfh.2023.74009.1456

Abstract

Introduction: Vascular endothelial dysfunction is one of the consequences of obesity or increased body fat mass. This study aimed to determining the effect of TRX training on myeloperoxidase (MPO) and total antioxidant capacity (TAC) as markers of vascular endothelial function in inactive obese women. Methods: 28 inactive middle-aged obese women aged 42±3 years of old (30 ≤ BMI ≤ 36) were randomly divided into of TRX (8 weeks, 3days/weekly, n= 14) and control (no training, n = 14) groups. Fasting levels of TAC and MPO activity and anthropometric indices were measured before and 48 hours after lasting exercise session of groups. Independent and paired t -test use to compare inter and intra-group change of variables (P< 0.05). Results: No significant difference was found in TAC (P= 0.356) and MPO (P= 0.268) between groups at baseline (P> 0.05). TRX led to a significant increase in TAC activity compared (P= 0.004) but MPO remained no change by TRX (P= 0.459). None of these variables were changed in the control group (P > 0.05). Conclusion: Emphasizing the increase in TAC, it is concluded that TRX training are associated with improved vascular endothelial function in inactive obese women.

Keywords

Main Subjects

References

  1. Chamani K, Hamedinia MR, Moeinfard MR, Tayebeh Amiri Parsa T. The survey of pervalence of obesity and some factors of breeding and its related physical activities in females aged 30-50 years of the city of Bojnord. Journal of Sabzevar Medical University. 2022; 8(1): 13-21.
  2. Zhang M, Feng L, Li J, Chen L. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease. Curr Pharmacol Rep. 2016; 2:281-292.
  3. Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J. Gut microbiota and diabetes:  from pathogenesis to therapeutic perspective. Acta Diabetol. 2011; 48(4):257 -73.
  4. Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol. 2001 Mar; 158(3):879-91.
  5. Nicholls SJ, Hazen SL. Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1102-11.
  6. Vita JA, Brennan ML, Gokce N, Mann SA, Goormastic M, Shishehbor MH, et al. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation. 2004 Aug 31; 110(9):1134-9.
  7. Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, et al. Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apoli-poprotein A-I. J Biol Chem 2006; 281:9001-4.
  8. Maes M, Galecki P, Chang YS, Berk M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29; 35(3):676-92.
  9. Scharnagl H, Kleber ME, Genser B, Kickmaier S, Renner W, Weihrauch G, et al. Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography--the LURIC study. Int J Cardiol. 2014 Jun 1; 174(1):96-105.
  10. Nasi M, Patrizi G, Pizzi C, Landolfo M, Boriani G, Dei Cas A, Mattioli AV. The role of physical activity in individuals with cardiovascular risk factors: an opinion paper from Italian Society of Cardiology-Emilia Romagna-Marche and SIC-Sport. Journal of Cardiovascular Medicine. 2019; 20(10), 631-639.
  11. Kraus WE, Powell KE, Haskell WL, Janz KF, Campbell WW, Jakicic JM, et al. Physical Activity, All-Cause and Cardiovascular Mortality, and Cardiovascular Disease. Med Sci Sports Exerc. 2019 Jun;51(6):1270-1281
  12. Hejazi M, nezamdoost Z, Saghebjoo M. Effect of Twelve Weeks of Aerobic Training on Serum Levels of Leptin, Vaspin and Some Indicators of Oxidative Stress in Obese Middle-Aged Women. Iranian Journal of Endocrinology and Metabolism. 2014; 16 (2): 111-118.
  13. Shemshahi A, Askari Z, Hedayati M. The effect of a selected stationary training course on plasma myeloperoxidase in women. Journal of Exercise Physiology and physical activity.2011; 8: 647-652.
  14. Kosmata, A. Functional Exercise Training with the TRX Suspension Trainer in a Dysfunctional, Elderly Population. Department of Health and Exercise Science. 2014. A
  15. Dolati M, Ghazalian F, Abednatanzi H. The Effect of a Period of TRX Training on Lipid Profile and Body Composition in Overweight Women. International Journal of Sports Science 2017, 7(3): 151-158.
  16. Housini S L, Eizadi M. The effect of 8 weeks TRX training on glutathione peroxidase (GPx) and hydrogen peroxide (H2O2) in sedentary middle-aged obese men. RJMS 2020; 27 (5): 210-219.
  17. Gaedtke A, Morat T. Effects of two 12-week strengthening programmes on functional mobility, strength and balance of older adults: Comparison between TRX suspension training versus an elastic band resistance training. Central European Journal of Sport Sciences and Medicine. 2016; 13(1): 49-64.
  18. Timorthy L.G, Roche A.F, Martorell R. Anthropometric standardization reference Manual. Pediatric Exercise Science, 1988, 4:34-42.
  19. Housini S L, Eizadi M. The effect of 8 weeks TRX training on glutathione peroxidase (GPx) and hydrogen peroxide (H2O2) in sedentary middle-aged obese men. RJMS 2020; 27 (5):210-219.
  20. Carlsohn A, Rohn S, Mayer F, Schweigert FJ. Physical activity, antioxidant status, and protein modification in adolescent athletes. Med Sci Sports Exerc. 2010 Jun; 42(6):1131-9.
  21. Sari-Sarraf V, Amirsasan R, Zolfi H R. Effects of aerobic and exhaustive exercise on salivary and serum total antioxidant capacity and lipid peroxidation indicators in sedentary men. Feyz 2016; 20 (5) :427-434
  22. Pashazadeh F, Tofighi A, Asri Rezaei S, Tolouei Azar J. Effect of aerobic exercises on oxidative stress indices in heart tissue of male Wistar rats after poisoning with Bisphenol A. J Gorgan Univ Med Sci. 2021; 22 (4) :54-62
  23. de Sousa CV, Sales MM, Rosa TS, Lewis JE, de Andrade RV, Simões HG. The antioxidant effect of exercise: a systematic review and meta-analysis. Sports medicine. 2017; 47(2), 277-293.‏
  24. Lira Ferrari GS, Bucalen Ferrari CK. Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging. Frontiers in Life Science. 23011; 5(3-4), 81-90.‏
  25. Brites F, Travacio M, Gambino G, Jaita G, Verona J, Llesuy S, Wikinski R. Regular exercise improves lipid and antioxidant profile. Atherosclerosis. 2011; 1(151), 261.‏
  26. Al-Qattan KK, Thomson M, Al-Mutawa'a S, Al-Hajeri D, Drobiova H, Ali M. Nitric oxide mediates the blood-pressure lowering effect of garlic in the rat two-kidney, one-clip model of hypertension. J Nutr. 2006 Mar; 136(3 Suppl):774S-776S.
  27. Rahimi Moghaddam SR, Elmieh A, Fadaei MR. Acute response of myeloperoxidase and total cancer status to increasing exercise activities in trained and non-trained middle-aged men. Metabolism and Exercise A bioannual journal. 2020; 10(1): 79-90.
  28. Ojaghi A, Ghazalian F, Vahdatpour T, Vahedi P, Abednatanzi H, Badalzadeh R. The effect of progressive endurance training on heart resistance induced by infusion ischemia in healthy male rats. Daneshvar Medicine 2021; 29(2):67-77.
  29. Quindry JC, Schreiber L, Hosick P, Wrieden J, Irwin JM, Hoyt E. Mitochondrial KATP channel inhibition blunts arrhythmia protection in ischemic exercised hearts. Am J Physiol Heart Circ Physiol. 2010 Jul; 299(1):H175-83. ‏
  30. Tang WHW, Katz R, Brennan ML, Aviles RJ, Tracy RP, Psaty BM, et al. Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure. Am J Cardiol 2009; 103:1269-74.
  31. Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood. 1997 May 15; 89(10):3503-21. ‏
  32. Hazen SL, Hsu FF, Duffin K, Heinecke JW. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols. J Biol Chem. 1996 Sep 20; 271(38):23080-8.
  33. McMurray F, Patten DA, Harper ME. Reactive Oxygen Species and Oxidative Stress in Obesity Recent Findings and Empirical Approaches. Obesity (Silver Spring). 2016 Nov; 24(11):2301-2310.
  34. Görlach A, Dimova EY, Petry A, Martínez-Ruiz A, Hernansanz-Agustín P, Rolo AP, et al. Reactive oxygen species nutrition hypoxia and diseases: problems solved? Redox Biol. 2015 Dec; 6:372-385.
  35. Linda S Pescatello, Ross Arena, Deborah Riebe, Paul D. Reviewed by Brad Ferguson. ACSM's guidelines for exercise testing and prescription. J Can Chiropr Assoc. 2014 Sep; 58(3): 328.
  36. Cosio-Lima LM, Reynolds KL, Winter C, Paolone V, Jones MT. Effects of physioball and conventional floor exercises on early phase adaptations in back and abdominal core stability and balance in women. The Journal of Strength & Conditioning Research. 2003; 17(4):721-5.
  37. Banz WJ, Maher MA, Thompson WG, Bassett DR, Moore W, Ashraf M, et al. Effects of resistance versus aerobic training on coronary artery disease risk factors. Experimental Biology and Medicine. 2003; 228(4):434-40.
Journal of Nutrition,Fasting and Health
Volume 11, Issue 3
September 2023

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History

  • Receive Date: 26 July 2023
  • Revise Date: 28 August 2023
  • Accept Date: 29 August 2023
  • First Publish Date: 29 August 2023

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