Document Type : Research Paper
Department of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University Tehran, Iran.
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
Department of Physical Education and Sports Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, the prevalence of which is increasing. The purpose of this study is to investigate the simultaneous effect of atorvastatin and combined training in NAFLD-induced rats. Methods: Twenty-one male Wistar rats were divided into 2 groups: 1) HFFD + combined training + atorvastatin, 2) HFFD + atorvastatin. The groups received HFFD for 15 weeks to induce NAFLD. Atorvastatin was administrated at the dose of 2 mg/kg/day. The interventions (atorvastatin and combined training) wrer done for 8 weeks. Results: Alanine transaminase (ALT) were significantly reduced and high-density lipoprotein (HDL) were increased in the HFFD + atorvastatin group. Low-density lipoprotein (LDL) decreased significantly in the HFFD + combined training + atorvastatin. There was no significant difference in the aspartate transaminase (AST), triglyceride (TG), alkaline phosphatase (ALP), and weight between the groups. Conclusion: Atorvastatin along with combined training leads to improvement of NAFLD. Therefore, they can be used to reduce the complications of NAFLD. Although more studies are needed to confirm the results.