The Effect of Saffron Extract Consumption Along With Aerobic Training on Glycemic Indices in Streptozotocin (STZ)-Induced Diabetic Male Wistar Rats

Document Type : Research Paper


1 Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran.

2 Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran.


Introduction: Diabetes, as one of the most common chronic diseases and one of the main causes. Death is known all over the world. The purpose of this study is to investigate the effect of extract consumption. Saffron combined with aerobic exercise on glycemic indices of diabetic male rats. It was with streptozotocin.  Method: The investigation method of this experimental study was carried out on 40 adult male rats with an age range of 10-12 weeks and a weight of 220-250 grams.So from the induction of diabetes in rats randomly to healthy control groups, diabetic control, Diabetic exercise, diabetic saffron and diabetic exercise + saffron group were divided. The duration of the intervention was 5 days a week and 8 weeks with moderate intensity. After some time 8 weeks of glycemic indices were measured, the data with Kolmogorov statistical tests Smirnov, one-way analysis of variance and Tukey's follow-up test were analyzed. Result: The results showed that fasting glucose in the saffron extract group with exercise Aerobics was significantly lower than the control group and lower than the aerobic training group (p=0.014). Glycosylated hemoglobin in the saffron extract group with aerobic exercise. It was lower than the control group (p=0.001) insulin resistance in the saffron consumption group. With aerobic exercise, it was lower than the control group (p=0.001). Conclusion: It is concluded that probably both an aerobic exercise course and a course Consumption of saffron extract by reducing hyperglycemic indicators can prevent diabetes to control It seems that if aerobic exercise and consumption of saffron extract at the same time used, can lead to more beneficial effects in this regard.


Main Subjects

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Volume 12, Issue 1
March 2024
Pages 36-41
  • Receive Date: 23 September 2023
  • Revise Date: 24 December 2023
  • Accept Date: 25 December 2023